Effects of atorvastatin on inflammatory factors in patients with acute coronary syndrome

Abstract

Objective To explore the effects of the atorvastatin with high-sensitivity C-reactive protein (Hs-CRP),IL-6,IL-8,IL-10 levels in patients with acute coronary syndrome (ACS).Methods 96 cases of patients with ACS were randomly divided into the low-dose group (atorvastatin 10 g/d),the high-dose group (atorvastatin 40 g/d) and the control group,32cases in each group,the three groups were compared with Hs-CRP concentration and IL-6,IL-8,IL-10 levels of prior treatment and post treatment by 1 week,2 weeks and 3 weeks respectively.Hs-CRP was measured by immune turbidimetric method,Plasma IL-6,IL-8,IL-10 levels were measured by ELISA.Results Before treatment the Hs-CRP,IL-6,IL-8,IL-10 levels in three groups showed no significant difference (P＞0.05); compared with prior treatment,the Hs-CRP,IL-6,IL-8 and IL-10 levels of each group decreased after treatment for 1 week,2 weeks,3 weeks,the difference was statistically significant (P＜0.05); the Hs-CRP,IL-6,IL-8 levels of the low-dose group and the high-dose group were significantly lower compared with those of the control group,the difference was statistically significant (P＜0.05),but the level of IL-10 showed no significant difference (P＞0.05).The Hs-CRP,IL-6,IL-8 levels of the high-dose group were lower than those of the low-dose group,the difference was statistically significant (P＜0.05); IL-10 level showed no significant difference (P＞0.05).Conclusion Atorvastatin can effectively improve the inflammatory response of patients with ACS,the action of high dose was more notable than that of low dose. Key words: Atorvastatin; Acute coronary syndrome (ACS); High-sensitivity C-reactive protein (Hs-CRP); Cytokines