Abstract

Structural remodeling of pulmonary artery plays an important role in the maintaining of sustained pulmonary arterial hypertension (PAH). The anti-remodeling effects of statins have been reported in systemic hypertension. In this study, we investigated the effects of Ato and losartan (Los) on monocrotaline-induced pulmonary artery remodeling in rats. Forty SD rats were assigned into: normal control (Ctr), PAH, Los, Ato treated groups. The mean pulmonary arterial pressure was reduced by Los and Ato treatment (mmHg: PAH, 36.1 4.2; Los, 29.8 4.8; Ato, 27.6 4.1; P<0.05).

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