Abstract
Objective To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2019 were elected as research subjects. Among them, 69 cases of patients who received treatment of arteriovenous thrombolysis were considered as group A, and 74 cases of patients who received treatment of arteriovenous thrombolysis combined with mechanical thrombectomy were considered as group B. NIHSS score, clinical efficacy, vascular recanalization, adverse reactions, hemodynamics, neurological injury indexes, duration of coma, length of hospital stay, and prognosis of patients in the two groups were compared. Results After treatment, the NIHSS score of group A was higher than that of group B (P < 0.05), the clinical efficacy of group B was better than that of group A, and the incidence of adverse reactions was lower than that of group A (P < 0.05). There was no difference in vascular recanalization rate, duration of coma, and prognosis between the two groups (P > 0.05). Length of hospital stay, maximum peak velocity after treatment (Vs), and mean flow rate (Vm) of group A were lower than those of group B, while vascular resistance index (RI), pulsatility index (PI), serum glutamic acid (Glu), neuron-specific enolase (NES), and S100β protein detected by enzyme-linked immunosorbent assay (ELISA) of group A were higher than those of group B (P < 0.05). Conclusion Arteriovenous thrombolysis combined with mechanical thrombectomy has a significant effect on ACI, with high safety and quick effect. In addition, it has a stronger effect on improving and protecting the neurological function of patients, which is worth promoting in clinical practice.
Highlights
Acute cerebral infarction (ACI) refers to brain necrosis caused by sudden dearterialization of the brain
A total of 143 cases of patients with ACI admitted to our hospital from June 2017 to June 2019 were selected as research subjects to perform prospective analysis
74 cases of patients who received treatment of arteriovenous thrombolysis combined with mechanical thrombectomy were considered as group B
Summary
Acute cerebral infarction (ACI) refers to brain necrosis caused by sudden dearterialization of the brain. This is usually due to atherosclerosis or thrombosis in the arteries supplying blood to the brain, leading to luminal stenosis or even occlusion, resulting in focal acute insufficient blood supply [1, 2]. Traditional conventional treatment measures can effectively attenuate the clinical symptoms of patients with cerebral infarction, the prognosis is not ideal, and the recurrence of the disease is extremely common [8]. Finding an effective treatment method for ACI and improving the prognosis of patients is the focus and difficulty of the current clinical studies
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