Abstract
1. The in vitro metabolism of the volatile aromatic hydrocarbon toluene by enzymes associated with the 12,000 g supernatant fraction of hybrid sunfish ( Lepomis macrochirus × L. cyanellus × L. gibbosus) liver homogenates was studied. 2. Aminopyrine demethylase (APDM) and aniline hydroxylase (AH) activities were measured. 3. Intramuscular injections of Aroclor 1254 (a polychlorinated biphenyl) produced significant increases in APDM and AH activities ( P ≤ 0.1, ANOVA). There were no significant changes in the metabolism of toluene, liver wet weights, or liver protein concentrations following treatment.
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