Abstract
• In the domestic hen, the uterine portion of the oviduct responded in vitro to arginine vasotocin (AVT) and prostaglandin E 1 (PGE 1) at all investigated stages of the egg-laying cycle. However, the uterus was less responsive to both hormones during oviposition. • The injections of these hormones provoked premature oviposition and a significant pressure increase in the uterus. In vitro and in vivo AVT was a more potent uterine stimulant than PGE 1. Indomethacin, an inhibitor of prostaglandin biosynthesis, antagonized in vitro the contractor activity of AVT but not that of PGE 1. Prostaglandin-like activity was demonstrated in the hen uterine tissue at the time of oviposition. It is concluded that AVT may cause uterine contractions via a prostaglandin activated mechanism.
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