Abstract
Rats were administered increasing doses of haloperidol or control solution for 25 days. 72 hr after drug withdawal they were observed for rearing activity in an open field with or without apomorphine treatment. 2. Rearing frequency was higher in haloperidol withdrawn rats. 3. In control rats rearing frequency decreased 15 min after apomorphine administration in a dose-dependent way. 4. In haloperidol withdrawn animals the apomorphine effects were dual, first an increase in rearing frequency induced by the smaller apomorphine doses (0.025-0.1 mg/kg) was observed and secondly a progressive and dose-dependent decrease was scored. 5. Apomorphine also induced different motor effects not necessarily similar in control and experimental rats. 6. Supersensitivity of dopaminergic receptors induced by the long-term neuroleptic administration was considered to be involved with the difference observed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
