Abstract
Abstract The effects of anxiolytics like diazepam, tofisopam and chlorpropanol—a beta adrenergic inhibitor—were investigated in rats subjected to stressful stimuli. Catecholamines and DOPAC (3,4-dihydroxy-phenylacetic acid) levels in brain cortical areas and in the median eminence, as well as plasma prolactin and corticosterone concentrations, were measured. (1) Electric foot shock increased the DOPAC level in the frontopolar, entorhinal and cingular cortex. (2) This increase in the frontopolar cortex was inhibited by diazepam and chlorpropanol, but not by tofisopam. (3) No change in catecholamine or DOPAC level was obtained in the median eminence of stressed or drug-treated animals. (4) Both tofisopam and diazepam increased the noradrenaline level in the olfactory bulb of rats subjected to electric foot shock stress. (5) The increase of corticosterone and prolactin secretion induced by foot shock or by swimming-induced stress were not influenced by anxiolytics.
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