Abstract
AbstractMigration inhibition experiments were performed with mixtures of sensitized human lymphocytes and guinea pig peritoneal exudate cells. Treatment of human lymphocytes with a rabbit anti‐human light chain serum (ALCS) abolished their capacity to cause antigen‐induced migration inhibition, whereas treatment with anti‐heavy chain sera did not. The specificity of ALCS was confirmed by absorption studies. The finding that anti‐heavy chain sera did not influence migration inhibition is consistent with other evidence that B cells are not directly involved in the migration inhibition process. The results provide indirect evidence that the — presumably thymus‐dependent — lymphocytes primarily involved in the migration inhibition process carry light chain determinants on their membrane.
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