Abstract
Diphenhydramine and phenindamine were administered in various doses to cats and the time course of changes in monoamine metabolite levels in cerebrospinal fluid was determined. Diphenhydramine at a sedative dose did not alter 5-hydroxytryptamine or dopamine metabolism. Excitant doses of diphenhydramine elevated 5-hydroxyindolacetic acid levels, while homovanillic acid levels remained unchanged. At a convulsant dose, diphenhydramine lowered rectal temperature while elevating both 5-hydroxyindolacetic acid and homovanillic acid levels. Phenindamine, which reportedly produces only central nervous system (CNS) excitation and convulsions, caused excitation, tremor and stereotypy, while elevating 5-hydroxyindolacetic acid and homovanillic acid levels in cerebrospinal fluid. These data suggest that antihistaminic-induced sedation is not due to an alteration in brain 5-hydroxytryptamine or dopamine metabolism and that only 5-hydroxytryptamine metabolism is increased during CNS excitation. Stereotypic behavior after phenindamine may occur through a dopaminergic system as reflected by elevated levels of homovanillic acid in cerebrospinal fluid.
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