Abstract
A series of antihistamines representing many structural types and pharmacological spectra antagonized isolation-induced fighting in mice. Antagonism of fighting by these compounds was correlated with anti-cholinergic potency as measured by prevention of physostigmine-induced lethality but did not correlate with antihistaminic or anti-tetrabenazine potency. Antagomism of fighting was not related to effects of these drugs on spontaneous motor activity.
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