Abstract
A serial mating method employing male mice for testing the antifertility effects of various drugs is described. Each male mouse was caged with 2 different females on Weeks 3-6 of the test. Successive matings insure that germ cells present in all the various stages of development at the time of drug treatment are sampled and tested. The drugs Thiotepa nitrofurazone Win 18446 and nafoxadine were tested with their antifertility effects measured by the number of viable fetuses in the mated females as revealed by autopsy 10 days after mating. Significant reduction of the number of fetuses was caused by Thiotepa at doses as low as .05 mg/day by nitrofurazone at doses as low as 2 mg/day and by Win 18446 at doses of 6 mg/day. Thiotepa caused the greatest fertility reduction while nafoxadine had no antifertility effect at all. It is concluded that serial mating of mice is an effective experimental technique for antifertility drug testing.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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