Abstract
consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy, several studies have reported that the patients commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum total Cholesterol, High Density Lipoproteins Cholesterol (HDL-C) Low Density lipoprotein Cholesterol ( LDL-C ) levels and Triglyceride (TG) .The aim of this study to assess and compare serum lipid profile of young adult patients treated by anti-epileptic drugs (phenytoin, oxcarbazepine and valproic acid) . Materials and Methods a cross-sectional study was conducted in Aljazeera state. Epileptic patients were of recruited. and taking antiepileptic drugs for more than six months and on regular follow up; approximately 120 patients on commonly used antiepileptic drugs (40 on phenytoin, 40 on oxcarbazepine, 40 on valproic Acid). Age and sex matching 40 controls were taken. our results show significant difference in the of mean TC, TG, HDL, and LDL-C levels in the group receiving phenytoin for more than six months when compared with control group P value (0.00) for all lipid profile. Also significant difference between the mean of TC, TG, HDL-C and LDL-C levels in the group receiving oxcarbazepine for more than six months when compared with control P value (0.00 ) for all lipid profile. From the present study we concluded that CYP enzyme inducer anti-epileptic medicines like phenytoin and oxcarbazepine is strongly associated with increased levels of TC, LDL-C, HDL-C and TG, where asvalproate showed no significant change. Therefore, the serum cholesterol level should be regularly monitored in patients undergoing. Therapy with inducer anti-epileptic medicines.
Highlights
Epilepsy refers to a disorder of brain characterized by the periodic and unpredictable occurrence of seizure [1]
We observed statistically significant difference in the mean of total cholesterol (TC), TG, High Density Lipoproteins Cholesterol (HDL-C), and LDL-C levels in the case group receiving anti-epileptic drug for more than six months when compared with control group The mean TC, TG, HDLC, LDL-C and levels were (168.9 ± 11.16 / 156.6 ± 8.5) mg/dl, (135.5 ± 11.65 /126.55 ± 20.5 ) mg/dl, (74.4167±9.71059 / 65.5 ± 5.3 ) mg/dl,( 76.9 ± 8.3 / 69.1 ± 6.7 ) mg/dl, respectively p value (0.00) shown in Table (1)
We find statistically significant difference in the mean of TC, TG, HDL-C LDL-C levels in the group receiving phenytoin, for more than six month when compared with control group The mean TC, TG, HDL-C, LDL-C and levels were (172.5 ± 8.9 / 156.6 ±8.5 ) mg/dl,( 140.7 ± 9.7 / 126.6 ± 20.5 ) mg/dl,( 76.3 ±10.23 / 65.5 ± 5.27 ) mg/dl,( 80.0 ±8.8 / 69.1 ± 6.7 )mg/dl, respectively p value (0.00) shown in Table (2)
Summary
Epilepsy refers to a disorder of brain characterized by the periodic and unpredictable occurrence of seizure [1]. The term ‘Seizure’ refers to a transient alteration of behaviour due to the disordered , synchronous, And rhythmic firing of populations of brain neuron [2]. WHO, epilepsy is one of the most common serious brain disorder that affects the individual , and disturbs the family and the society in general [3]. Epilepsy can be considered a spectrum disorder because of its different causes , different seizure types , its ability to vary in severity and impact from person to person and its range of co-existing conditions [4]. Some people have seizures very infrequently, while Terms in italics appear in a Glossary found at the end of this document [6]
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