Abstract
The effect of changing antiepileptic drug concentrations within the therapeutic range on the EEGs of epileptic subjects was studied by quantitative EEG analysis. Twenty-seven patients had administration of one or more drugs discontinued on admission to the hospital for prolonged video/EEG monitoring, and drug levels were correlated daily with the simultaneous EEG background. Phenytoin, alone or in combination with other drugs, led to significant changes in the mean EEG background frequency and increased the percentage of power in the theta and delta bands. In the plasma ranges studied, carbamazepine, phenobarbital, and valproic acid did not lead to significant change in the EEG background frequency; however, the number of subjects taking these medications was small.
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