Abstract
The effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition of acoustic startle response were determined in mice. The prepulse inhibition is associated with sensorimotor information processing in the brain. The anticholinergic agent scopolamine (0.3 mg/kg, s.c.) significantly attenuated prepulse inhibition, while the drug (1–10 mg/kg, s.c.) had no effects on startle amplitude as an indicator of startle response. The muscarinic M1 receptor antagonist pirenzepine (0.1–10 μg/mouse, i.c.v.) and the muscarinic M2 receptor antagonist AF-DX116 (11-[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one) (0.1–10 μg/mouse, i.c.v.) had no effects on prepulse inhibition or startle amplitude. The muscarinic M3 receptor antagonist 4-DAMP (1,1-dimethyl-4-diphenylacetoxy-piperidinium iodide) (30 μg/mouse, i.c.v.) and the muscarinic M4 receptor antagonist tropicamide (0.1 μg/mouse, i.c.v.) significantly attenuated prepulse inhibition, while tropicamide (0.01 μg/mouse, i.c.v.) but not 4-DAMP (10 and 30 μg/mouse, i.c.v.) produced a significant increase in startle amplitude. These results suggest that the blockade of muscarinic M3 and M4 receptors leads to the disruption of prepulse inhibition.
Published Version
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