Abstract
The influence of cotton pellet inflammation in rats and the effect of prednisolone and indomethacin on the excretion of the main urinary metabolite (MUM)s of prostaglandin (PG) F and E types were studied. After cotton pellet implantation, the excretion of PGE-MUM and F-MUM was progressively increased. In the early phase of inflammation, the excretion of PGE-MUM and PGF-MUM was suppressed by administration of indomethacin. However, prednisolone suppressed only PGF-MUM excretion in the early phase of inflammation. These results indicate that no direct interaction was obtained between the inhibition of the inflammatory response by prednisolone and indomethacin and PGs-MUM excretion in inflamed rats.
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