Effects of anti-inflammatory drugs on glutathione levels and liver succinic dehydrogenase activity in carrageenin edema and cotton pellet granuloma in rats

Abstract

Effects of anti-inflammatory drugs, hydrocortisone, phenylbutazone and indomethacin, on blood and liver glutathione (GSH) levels and liver succinic dehydrogenase (SDH) in carrageenin edema and cotton pellet granuloma have been investigated in male albino rats. No significant changes in liver and blood GSH levels during carrageenin edema and cotton pellet granuloma were observed. Liver GSH levels were lowered significantly by these anti-inflammatory drugs in rats with both types of inflammation and also in normal rats. However, blood GSH levels were not altered significantly by these drugs in carrageenin-treated and normal rats except with indomethacin which lowered blood GSH levels both in normal and carrageenin-treated rats. These drugs lowered blood GSH both in rats with cotton pellet granuloma and in normal rats. Liver SDH activity was significantly increased in carrageenin edema and cotton pellet granuloma. Pretreatment with hydrocortisone, phenylbutazone, and indomethacin inhibited significantly the increased liver SDH activity in carrageenin edema and cotton pellet granuloma. These drugs did not inhibit significantly the liver SDH activity in normal rats. These results have been discussed in relation to their implications on intermediary metabolism.