Abstract
Satisfactory ultrastructural integrity of the mouse diaphragm was maintained in vitro in modified Krebs-Henseleit saline for 3h when the rate of oxygenation was 2.8 ml sec −1 (95% O 2 + 5% CO 2). Hypoxic (O 2 = 1.6 – 2.0 ml sec −1) or anoxic (95% N 2 + 5% CO 2) conditions triggered typical Ca-triggered myofilament damage, believed to be induced by a rise in [Ca] i. It was unaffected by omission of Ca from the saline, but the muscle was protected at 7.8 °C. ‘High-O 2’ gassing (10 ml sec −1) also caused a characteristic, but different, damage with swollen sarcoplasmic reticulum and spacing of the myofibrils.
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