Abstract
s / Brain Stimulation 8 (2015) 326e342 331 stimulator with high-voltage tolerance in a 0.18mm 1.8V/3.3V CMOS process, three 3.3V PMOS and three 3.3V NMOS transistors are utilized in this work. Although the operating voltage may be up to 10V, the high-voltage-tolerant stimulator fabricated in the 0.18mm 1.8V/3.3V CMOS process can be safely used. To be able to deliver biphasic stimulation current to the brain tissue, the stimulator uses an H-bridge at its output. The fabricated chipof the electrical stimulatorhas been integrated into a closed-loop epileptic seizure monitoring and controlling system for animal tests. After stimulation, the intensive and rapidly brain activity in Long-Evans rat with epileptic seizure is suppressed. According to the animal test results, the functionalities of the highvoltage-tolerant stimulator have been successfully verified. Acknowledgment: This work was supported by Ministry of Science and Technology, Taiwan, under Contract MOST 103-2220-E009-007 and MOST 103-2220-E-003-001, and by Biomedical Electronics Translational Research Center, National Chiao Tung University, Taiwan.
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