Abstract
Background and Aims: ANGPLT3 protein is known to be involved in the inhibitory regulation of extracellular lipases (LPL and HL). Thereby, its absence has been shown to increases the lipolytic degradation of TG-rich lipoproteins. Recently, we have reported that ANGPTL3 may also influence fatty acid (FFA), which are important substrates for energy production. In particular, we found that ANGPTL3 can influence lipolysis in 3T3-L1 adipocytes throughout a biphasic action strictly depending on the presence or absence of β-adrenergic stimulation. If this mechanism is also acting in muscles tissue is not known. Therefore, our primary purpose was to evaluated the effects of ANGPTL3 in C2C12 muscle cells. This would allow improving our knowledge about the role of ANGPTL3 as also a regulator of energy substrate utilization.
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