Abstract

In 33 human subjects with a sound circulatory system regional cerebral blood flow changes, following intracarotid injection of sodium methylglucamine diatrizoate (Angiografin, Urografin 76%) during cerebral angiography, were investigated. Angiografin®, at the start of recording 1 and 3 min after intracarotid injection, caused an increase of rCBF of 15.7% and 7.8% respectively. Urografin®, 3 min after completion of intracarotid injection, brought about an increase of rCBF of 23.0%. Under the action of both X-ray radiopaque materials at the start of rCBF-measurement, 5 and 8 min after completed intracarotid injection, there no longer was a significant difference from the resting values. Changes in haemodynamics (blood pressure, pulse rate) during carotid cerebral angiography with sodium-methylglucamine diatrizoate (Angiografin, Urografin 76%) were not observed in this study.

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