Abstract
Anesthetic agents can alter hepatic glucuronidation. Under diethyl ether (E), pentobarbital (P) or ketamine (K) (n=5 each), rats received bile duct and venous catheters. Basal bile was collected for 300 min without further anesthesia. Bilirubin diglucuronide (DG) was quantified by HPLC, total bilirubin excretion (μg/100 gm body wt/min) by Van den Bergh analysis and bile flow (μ1/100 gm body wt/min) by weight.E anesthesia is associated with a reversible suppression of DG formation and total bilirubin excretion. Flow and excretion are variable with K. P provided the most uniform excretion data.
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