Abstract
The 5α- and 5β-dihydrotestosterone (DHT) androgens relax KCl-induced tonic contraction in rat uterus, in a dose-dependent way. The 5α and 5β-DHT relaxing effect is counteracted by CaCl 2 (0.1–10 mM). The 5α-DHT, but not the 5β-DHT, effect was reduced by cycloheximide (10 μg/ml) and by actinomycin D (5 μg/ml). Flutamide at 10 −6 M shifted the effect of 5α-DHT to the right. However, other doses of flutamide or cyproterone acetate did not modify the effect of both androgens. We suggest a non-genomic effect of 5α-DHT and 5β-DHT in rat uterus contraction but that intracellular and genomic actions play a part in the relaxing effect of 5α-DHT.
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