Abstract
Purpose: To evaluate wound healing in diabetic rats by using topic Andiroba oil (Carapa guianensis).
 Methods: Six male, adult, Wistar rats were distributed into three groups: Sham group (wound treatment with distilled water); Collagenase group (treatment with collagenase ointment); and Andiroba group (wound treatment with Andiroba oil). The wound was evaluated considering the macroscopic and microscopic parameters.
 Results: The results indicated differences in the healing of incisional wounds between treatments when compared to control group. Accelerated wound healing was observed in the group treated with Andiroba oil and Collagenase in comparison to control group, especially after the 14th day. Morphometric data confirmed the structural findings.
 Conclusion: There was significant effect in topical application of Andiroba oil on wound healing in rats with induced diabetes.
 
 Keywords: Medicinal plants. Diabetes Mellitus. Wound healing. Rats.
Highlights
Diabetes mellitus (DM) is the chronic metabolic disease that determines hyperglycemia state that causes damage to blood vessels, heart, eyes, kidneys and nerves
The animals were kept in a vivarium of Federal University of Pará (UFPA) with a controlled temperature, light, humidity, and noise; water and food was provided ad libitum
Multiple sections were analyzed with regard to the presence of re-epithelialization, intensity of local inflammatory reaction, type of inflammatory response as the predominant cell, the presence of granulation tissue, neovascularization and fibrosis [8]
Summary
Diabetes mellitus (DM) is the chronic metabolic disease that determines hyperglycemia state that causes damage to blood vessels, heart, eyes, kidneys and nerves. The hyperglycemic state of DM determines a state of poor healing where these ulcers can evolve with necrosis and amputation of the lower limb To avoid such an outcome, alternatives are sought to improve this healing and medicinal plants with their various properties being discovered may be effective with the advantage of lower cost compared to the standard treatment of diabetic foot ulcers [2, 3]. Already described with this great potential, Andiroba oil (Carapa guianensis), is used in popular culture with healing purpose. Research has shown that the use of oil effectively participates in wound healing promoting the formation of granulation tissue, tissue contraction and epithelialization [4, 5]
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