Abstract
Body-surface gastric mapping (BSGM) measures the resultant body-surface potentials of gastric slow waves using an array of cutaneous electrodes. However, there is no established protocol to guide the placement of the mapping array and to account for the effects of biodiversity on the interpretation of BSGM data. This study aims to quantify the effect of anatomical variation of the stomach on body surface potentials. To this end, 93 subject specific models of the stomach and torso were developed, based on data obtained from the Cancer Imaging Archive. For each subject a set of points were created to model general anatomy the stomach and the torso, using a finite element mesh. A bidomain model was used to simulate the gastric slow waves in the antegrade wave (AW) direction and formation of colliding waves (CW). A forward modeling approach was employed to simulate body-surface potentials from the equivaelent dipoles. Simulated data were sampled from a 5 × 5 array of electrodes from the body-surface and compared between AW and CW cases. Anatomical parameters such as the Euclidean distance from the xiphoid process (8.6 ± 2.2 cm), orientation relative to the axial plane (195 ± 20.0°) were quantified. Electrophysiological simulations of AW and CW were both correlated to specific metrics derived from BSGM signals. In general, the maximum amplitude ( ∆ ϕ) and orientation ( θ) of the signals provided consistent separation of AW and CW. The findings of this study will aid gastric BSGM electrode array design and placement protocol in clinical practices.
Highlights
Motility of the stomach is a critical aspect of digestion, as it serves to break down the ingested food and mix with gastric secretions
This study demonstrated a simulation-based analysis of the population variations of gastric anatomy and its influence on the ability of using multi-channel body-surface gastric mapping (BSGM) to distinguish between antegrade wavefronts (AW) and colliding wavefronts (CW)
While significant anatomical variations existed in the cohort of populations studied, features in the BSGM were able to distinguish between colliding waves (CW) and AW
Summary
Motility (contraction) of the stomach is a critical aspect of digestion, as it serves to break down the ingested food and mix with gastric secretions. Slow waves propagate in a circumferential direction to form a ring around the gastric lumen and propagate towards the pylorus with varying amplitude and velocity, i.e. slower in the corpus (2.6-3.5 mm·s-1) and faster in the distal antrum (4.7-6.9 mm·s-1) [4]. It takes approximately 60 s for a single cycle of slow waves to reach the pylorus, resulting in three or more simultaneous wavefronts propagating in the human stomach [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
