Effects of anabolic steroids on glucose metabolism

Abstract

1) The administration of anabolic steroid causes aggravation of glucose tolerance, especially in daily aggravation in alloxanized subdiabetic rat.2) Anabolic steroid results in a decrease in ILA of the peripheral blood suggesting the probale cause in the liver and prolongation of ILA response on intravenous glucose injection is hardly considered to be derived from the pancreas.3) Treatment with anabolic steroid suppressed the glucose uptake of the animal fat tissue and the action of extrinsic insulin.4) The liver hexokinase activity was not influenced by the anabolic steroid.It is concluded that the action of diabetogenicity of anabolic steroid is considered to be toward the liver and the fat tissue rather than toward the pancreas.