Abstract
ObjectiveTo evaluate the effects of anabolic androgenic steroids (AAS) on chylomicron metabolism. MethodsAn artificial lipid emulsion labeled with radioactive cholesteryl ester (CE) and triglycerides (TG) mimicking chylomicrons was intravenously injected into individuals who regularly weight trained and made regular use of AAS (WT+AAS group), normolipidemic sedentary individuals (SDT group) and individuals who also regularly weight trained but did not use AAS (WT group). Fractional clearance rates (FCR) were determined by compartmental analysis for emulsion plasma decay curves. ResultsFCR-CE for the WT+AAS group was reduced (0.0073±0.0079min−1, 0.0155±0.0100min−1, 0.0149±0.0160min−1, respectively; p<0.05), FCR-TG was similar for both the WT and SDT groups. HDL-C plasma concentrations were lower in the WT+AAS group when compared to the WT and SDT groups (22±13; 41±7; 38±13mg/dL, respectively; p<0.001). Hepatic triglyceride lipase activity was greater in the WT+AAS group when compared to the WT and SDT groups (7243±1822; 3898±1232; 2058±749, respectively; p<0.001). However, no difference was observed for lipoprotein lipase activity. ConclusionsData strongly suggest that AAS may reduce the removal from the plasma of chylomicron remnants, which are known atherogenic factors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
