Effects of an oral supplement based on cucurbita maxima and capsicum annum on symptoms of overactive bladder in female population: an observational study

Abstract

IntroductionThe prevalence of overactive bladder (OAB) in women increases with age and is present in approximately 30 % of women over the age of 65 years. A high percentage of patients undergoing pharmacological therapy discontinue treatment for side effects and costs. Using an oral supplement (Kubiker®), consisting of vitamins, cucurbita maxima, capsicum annum, polygonum cuspidatum and l-Glutammin, for the control of urinary symptoms, could be a valid alternative. ObjectiveTo assess the efficacy and tolerability of this oral supplement in women affected by OAB. MethodsWe performed a retrospective, longitudinal, observational, cohort study of 84 patients affected by OAB, who received a prescription of Kubiker® for 12 weeks (2 tablets a day for the first month, then 1 tablet a day for 2 months). Primary outcome was to check the efficacy of therapy through questionnaire Patient global impression of improvement (PGI-I) after 12 weeks of therapy. The secondary outcome was to evaluate the difference in the answers of the Overactive Bladder Questionnaire (OAB-Q) before and after therapy. Adherence to therapy was also evaluated. ResultsData showed a positive effect of Kubiker® in the control of urinary symptoms after 12 weeks of therapy. Paired t-test used for the evaluation of OBS before and after the treatment showed a p-value < 0.001. The analysis of this questionnaire especially showed an improvement in the responses concerning the symptoms of urination urgency and urge incontinence. ConclusionTherapy with oral supplement based on vitamins (C and D), cucurbita maxima, capsicum annum, polygonum cuspidatum and l-Glutammin is an effective and well-tolerated treatment for overactive bladder.