Abstract
Objective To examine the efficacy and metabolic effects of a supervised combined aerobic and resistance exercise training program on both maximal and submaximal exercise capacity and glucose regulation in diabetic patients with symptomatic heart failure (HF). Materials and methods Twenty-one patients with HF, type 2 diabetes mellitus, and left ventricular ejection fraction less than 40% were randomized either to an exercise training program (n=10) or to usual care (n=11) for 24 weeks. Maximal and submaximal cardiopulmonary exercise testing and glucose metabolism using the homeostasis model of assessment-insulin resistance index were assessed at baseline and after 24 weeks.
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