Abstract
An adenine analog, 6-methylpurine, has been found to inhibit growth and synthesis in the yeast Candida utilis . The analog inhibits the synthesis of guanylic acid from adenylic acid, depresses the incorporation of adenine in ribonucleic acid, inhibits ribosomal synthesis, and leads to an altered distribution of amino acids in the cellular metabolic pool. 6-Methylpurine appears to act in this organism in a similar manner to 5-fluorouracil.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects
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