Abstract
Cyclic GMP and cyclic AMP levels were measured in the cerebella of mice treated with several drugs which affect CNS function. D-amphetamine produced a two fold increase in cyclic GMP levels, whereas chlorpromazine and reserpine reduced cyclic GMP levels 62% and 73%, respectively. The effect of d-amphetamine on cyclic GMP levels was blocked by chlorpromazine, but not by atropine. Chlorpromazine did not block the increase in cyclic GMP levels which follows oxotremorine treatment. None of the above agents altered cyclic AMP levels. These results offer further support for the concept that cyclic GMP is involved in neural function and is controlled by mechanisms independent of those regulating cyclic AMP metabolism.
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