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Abstract
BackgroundThe meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).MethodsEligible studies were retrieved through a comprehensive search of electronic databases and manual search. Then the high-quality studies met the rigorous inclusion and exclusion criteria, as well as related to the subject was selected for the study. Comprehensive data analyses were conducted using STATA software 12.0.ResultsThe study results revealed that CVD patients with CT + TT genotype of AMPD1 C34T polymorphism presented elevated left ventricular ejection fraction (LVEF) (%) and reduced left ventricular end diastolic dimension (LVEDD) (mm) as compared with CC genotype, moreover, the subgroup analysis found that the LVEF (%) was markedly higher in heart failure (HF) patients carrying CT + TT genotype than CC genotype. Besides, the systolic blood pressure (SBP) (mmHg) in CVD patients with CT + TT genotype was obviously decreased in contrast with the CC genotype. Patients suffered from HF with different genotypes (CT + TT and CC) of AMPD1 C34T polymorphism exhibited no significant differences in total survival rate and cardiac survival rate.ConclusionsOur current meta-analysis indicated that the T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in CVD patients, but had no effects on total survival rate and cardiac survival rate for HF.
Highlights
The meta-analysis was aimed to evaluate the effects of adenosine monophosphate deaminase 1 (AMPD1) gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD)
While several recent studies suggested that AMPD1 may play essential roles in the initiation and development of CVD, for instance, it has been demonstrated that AMPD1 allele mutation play a protective role during congestive heart failure (CHF) development, which contributed to prolong possibility of survival without cardiac transplantation [13], it can alleviate the aortic stiffness and inflammation for patients with coronary artery diseases (CAD) [10]
Baseline characteristics of included studies A total of 206 studies related to AMPD1 gene polymorphism and CVD (165 English studies and 41 Chinese articles) were retrieved in the initial literature search, of which 108 unrelated articles falling short of titles or abstracts were removed, and the remaining 94 articles were used for further screening
Summary
The meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD). While several recent studies suggested that AMPD1 may play essential roles in the initiation and development of CVD, for instance, it has been demonstrated that AMPD1 allele mutation play a protective role during congestive heart failure (CHF) development, which contributed to prolong possibility of survival without cardiac transplantation [13], it can alleviate the aortic stiffness and inflammation for patients with CAD [10]. There appears a need for a meta-analysis to investigate the relationship between the AMPD1 gene C34T variant and CVD risk regarding the aspects of cardiac indexes, blood pressure and prognosis, and thereby deriving a more plausible estimation for CVD
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