Abstract
To determine the effect of exposure of calcium channel blocker Amlodipine for different periods on the reproductive parameters of adult male Wistar albino rats Amlodipine in a dose equivalent to the normal clinical dose was administered orally to albino rats in their reproductive age for different periods ranging from two weeks to eighteen weeks and the reproductive parameters such as sperm count, motility and gonado-somatic index were verified. Reproductive parameters such as sperm count and sperm motility were found to be adversely affected in a significant (p<0.05) and duration dependent manner from 28th day onward of once daily administration of Amlodipine while gonado-somatic index was decreased significantly (p<0.05) from 42nd day of continuous administration Potential risk of the calcium channel blocker Amlodipine on male fertility, especially on long term use must be considered while prescribing this drug to young adults.
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