Abstract
Objective: To investigate the effects of single-drug or combination therapy of amlodipine and enalapril on aorta remodeling and its mechanisms. Methods: Renovascular hypertensive rats were induced by two kidney-one clip method, and were treated with normal saline (model group), amlodipine (5mg/kg), enalapril (10mg/(kg) and amlodipine+enalapril (2.5mg/kg+5mg/kg) for 6weeks. Sham-operated rats were treated with normal saline as controls. Aortic media, the ratio of media thickness/luminal diameter (MT/LD), media area/luminal area (MA/LA) and aortic tissue structure were observed by HE, immunohistochemistry and Masson staining.
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