Abstract
1. 1. Effects of aminooxyacetic acid (AOAA) on in vivo γ-aminobutyric acid system of rat oviduct have been studied. 2. 2. After i.p. injection of the drug of the oviduct GABA level becomes 50% of control values, GAD activity remains apparently unchanged while GABA-T activity decreases. 3. 3. The radioactive GABA found in oviducts incubated in the presence of l-[U- 14C]glutamate, decreases with increasing concentrations of AOAA through the inhibition of l-glutamate decarboxylase. 4. 4. GABA decrease seen in vivo after AOAA administration is probably due to GAD inhibition.
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