Abstract
Aminoacetonitrile Cu 2+-containing “pyridoxal” amine oxidases but not flavin-containing amine oxidases. Pargyline inhibits only flavin-containing amine oxidases. Propargylamine, on the other hand, inhibits both types of enzyme. We have used these inhibitors to study mescaline metabolism in the rabbit. Mescaline rapidly undergoes oxidative deamination to 3,4,5-trimethoxyphenylacetic acid in the control and pargyline-treated rabbits. In the aminoacetonitrile- and propargyline-treated animals, mescaline oxidation is inhibited and other metabolites, e.g. N-acetylmescaline, are formed. These results indicate that enzymes related to plasma enzymes (Cu 2+-containing “pyridoxal” amine oxidases) are primarily responsible for the oxidation of mescaline in the rabbit. Similar enzymes are also present in the liver, lung and kidney of the rabbit.
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