Abstract
The cell body of the fast coxal depressor motoneurone (D f) was used to examine the effects of a group of putative amino acid neurotransmitters. γ-Aminobutyric acid (GABA) elicited a biphasic hyperpolarizing response, each component having a separate reversal potential. Both components were affected by the GABA antagonist picrotoxinin. l-Glutamate produced a hyperpolarizing response with a reversal potential of between −80 and −85 mV, and l-aspartate gave a similar but less potent effect. Kainic acid and quisqualic acid elicited depolarizing responses of up to 10 mV in amplitude. β-Alanine and taurine produced a single hyperpolarization with a reversal potential similar to glutamate. Glycine was ineffective on motoneurone D f.
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