Abstract
The effects of aluminum chloride (AlCl 3) on sodium current ( I Na), the transient outward potassium ( I A) and delayed rectifier potassium currents ( I K) in hippocampal CA1 neurons of rats were studied using the whole cell patch-clamp technique. AlCl 3 decreased I Na, I A, and I K in a partly reversible, dose and voltage-dependent manner. AlCl 3 prolonged the time to peak of I Na, and increased the inactivation time constants of I Na and I A. In addition, 1000 μM AlCl 3 shifted the voltage dependence of steady-state activation of I Na, I A and I K toward positive potential, and the voltage dependence of steady-state inactivation of I Na, I A toward negative potential. These results imply that AlCl 3 could affect the activation and inactivation courses of sodium current and potassium current of rat hippocampal CA1 neurons, which may contribute to damage of the central nervous system by aluminum.
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