Effects of Aluminium Chloride Exposure on the Histology of lungs of Wistar Rats

Abstract

Aluminium is ubiquitous element and the third most prevalent (abundant) element in the earth's crust. It is presents in many manufactured foods, medicines and is also added to drinking water for purification purposes. The purpose of this study was to evaluate the effects of aluminium chloride exposure on the histology of kidney of wistar rats. Twenty (20) adult wistar rats were used for this study. The animals were divided into five groups as follows: group I was the control that received distil water only, group II received 475mg kg -1 , group III received 950mgkg -1 , group IV received 1,425mg kg -1 and group V received 1,900mg kg -1 via oral intubation for duration of eight weeks. The wistar rats were humanely sacrificed and kidneys were removed and fixed in formalin. The kidneys were processed and stained using the routine haematoxylin and eosin staining method (H&E). The stained sections were examined under the light microscope fitted to a digital camera. Our results showed cavitations, glomerular atrophy and vacuolation of cytoplasm of the lining cells of both the proximal convoluted tubules (PCT) and distal convoluted tubules of the kidney in the treated groups when compared to the control group. Based on our observations, we therefore conclude that aluminium chloride exposure had detrimental effects on the histology of kidney of wistar rats.