Abstract
Giardia lamblia is one the most common human zoonotic protozoan affecting about 200 million peopleannually, but recurrent symptoms and drug resistance were reported in giardiasis patients. The presentstudy assessed the therapeutic effect of Tomex® and probiotics against giardiasis as well as evaluatedefficacy of chitosan nanoparticles and metronidazole. Sixty healthy male hamsters were dividedinto 6 groups. Each group consists of 10 hamsters as following: GI non-infected hamsters, GII infectedcontrol, GIII, GIV, GV & GVI infected with G. lamblia and treated with tomex, probiotics, chitosannanoparticles (CsNPs), and metronidazole (MTZ) respectively. Hamsters were orally infected with10,000 Giardia cysts. After 3 weeks stool samples were examined for Giardia samples and contentsfor intestinal histopathology and electron microscopy of Giardia trophozoite ultrastructure. The highestreduction in Giardia cyst and trophozoite were in hamsters received MTZ but with natural alternativetherapies chitosan nanoparticles showed a therapeutic effect with highest reduction in cyst andtrophozoite counts (80.59% & 76.55%) respectively and best recovery in intestinal pathology. MTZgave higher reduction rates (91.04% & 90.75%) respectively with normal intestinal histopathology.
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