Abstract
Abstract Cats injected with α-methyl-meta-tyrosine (50 mg/kg i.p.) exhibited a severe and prolonged (48 hr) inhibition of bar pressing for milk rewards which was concomitant with an increase in auditory evoked potentials recorded from both specific and nonspecific cortical projections as well as an increase in high amplitude slow wave activity in the general ECoG background. Subjects also displayed a marked but transitory increase (10 min–1 hr) in post-reinforcement electrocortical synchronization amplitude. Observation revealed no changes in home-cage eating behavior. Since the drug is known to reduce norepinephrine (NE) levels in the brain for at least 48 hr without markedly affecting dopamine or serotonin levels, it was hypothesized that NE is critical to the operation of nonspecific motivation and/or reinforcement in an appetitive instrumental conditioning situation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
