Effects of Alpha-Blocker on Sperm Concentration, Motility, Intraluminal Pressure and Fluid Movement in the Rat Cauda Epididymis

Abstract

Purpose To investigate whether alpha blocker has an effect on epididymal sperm parameters, intraluminal pressure and fluid movement. Materials and Methods Sprague-Dawley rats were given daily oral doses 1 mg./kg., 2 mg./kg., or 10 mg./kg. of Bunazosin, a selective alpha blocker, for 1 month. A micropuncture technique was used to collect intraluminal fluids. Results Epididymal sperm concentrations were significantly increased. Progressive motility of spermatozoa was not altered. Intraluminal pressures were significantly reduced, and intraluminal fluid movement rates were significantly increased. Conclusion Alpha blocker has an effect on sperm transport and storage in the rat testis and epididymis.