Abstract
This study was undertaken to determine simultaneously the effects of Alfuzosin on urethral and blood pressures in the same conscious male rat. Alfuzosin (i.v., 3, 10 and 30 μg/kg) dose-dependently decreased urethral pressure without affecting mean arterial blood pressure. At the higher dose, blood pressure was only slightly and transiently decreased while a marked decrease (−40%) in urethral pressure was observed. Therefore, this experimental model is suitable to assess uroselectivity.
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