Abstract
To determine the effects of alcohol and smoking on serum estrone levels among women assigned to hormone therapy. We analyzed the data from 676 participants in the Postmenopausal Estrogen/Progestin Interventions study. Those who consumed more than 5.5 g of alcohol daily demonstrated greater rises in serum estrone than those who drank less (>0 to < or =5.5 g/d) (P = 0.07) and those who were abstinent (P = 0.09). Current smokers had lesser gains in serum estrone compared with former smokers (P < 0.0001) and never smokers (P < 0.0001). Alcohol consumption augmented and smoking diminished serum estrone levels achieved while women were taking hormone therapy.
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