Abstract
It has been demonstrated that moderate alcohol consumption provides protection against the development of type 2 diabetes. However, several other reports suggested that moderate alcohol intake may increase the risk of type 2 diabetes in non-obese Japanese. The aim of present study was to investigate the effect of 1-week alcohol abstinence on hepatic insulin sensitivity and fasting plasma glucose (FPG) in non-obese Japanese men. We recruited 8 non-obese Japanese men with mildly elevated FPG and drinking habits alcohol (mean frequency; 5.6 ± 2.5 times/week, mean alcohol consumption; 32.1 ± 20.0 g/day). Before and after the 1-week alcohol abstinence, we used the 2-step hyperinsulinemic-euglycemic clamp to measure endogenous glucose production (EGP) and insulin sensitivity (IS) in muscle and liver. One-week alcohol abstinence significantly reduced both FPG by 7% (from 105.5 ± 11.7 to 98.2 ± 7.8 mg/dl, P < 0.01) and fasting EGP by 6% (from 84.1 ± 4.2 to 77.6 ± 1.6 mg/m2 per min, P < 0.01), respectively. Two–step clamp study showed that alcohol abstinence significantly improved hepatic-IS, but not muscle-IS. In conclusion, one week alcohol abstinence improved hepatic IS and FPG in non-obese Japanese men with mildly elevated FPG and drinking habits alcohol.
Highlights
The number of the patients with type 2 diabetes mellitus is rapidly growing worldwide and if effective methods to prevent its onset are discovered, we could reduce the health problem
By matching the record of alcohol intake of each subjects, for the first time, we found that alcohol consumption negatively correlated with hepatic insulin sensitivity, but not with muscle insulin sensitivity[14]
Given that our data showed that impaired hepatic insulin sensitivity correlated positively with fasting plasma glucose (FPG) level[14], alcohol intake may impair hepatic insulin sensitivity and increases FPG in non-obese non-diabetic Japanese
Summary
The number of the patients with type 2 diabetes mellitus is rapidly growing worldwide and if effective methods to prevent its onset are discovered, we could reduce the health problem. We applied two step hyperinsulinemic (IIR = 10 and 20 mU/m2/min) euglycemic clamp study with glucose tracer to precisely evaluate hepatic insulin sensitivity in non-obese non-diabetic Japanese[14,15]. Given that our data showed that impaired hepatic insulin sensitivity correlated positively with fasting plasma glucose (FPG) level[14], alcohol intake may impair hepatic insulin sensitivity and increases FPG in non-obese non-diabetic Japanese.
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