Abstract
A study has been made of the quantitative effects of Albizia gum on the mechanical and release properties of paracetamol tablets in comparison with gelatin using 2 3 factorial experimental design. The individual and combined effects of nature (N) and concentration of binder (C), and relative density of tablet (RD) on the mechanical tensile strength (TS) and friability (F) and drug release properties disintegration time (DT) and dissolution time (t 80 ) of the tablets were investigated. The ranking of the individual effects was C ≫ RD > N on TS and DT, RD > C > N on F and C > N > RD on t 80 . There were significant (p
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