Abstract
In this study, we investigated the SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) system doped with Ag. The antibacterial capacity of the system was determined by loading and delivering silver nanoparticles (AgNPs) through the porous structure of MBG. According to X-ray diffraction (XRD) and solid-state magic angle spinning nuclear magnetic resonance (solid-state MAS-NMR) result, Ag-doped MBG maintained its parent glassy structure. Further, the solid-state MAS-NMR results indicated that the Ag content did not influence the network connectivity of the glass substrate. On the other hand, transmission electron microscopy (TEM) images indicated that AgNPs (size < 5 nm) were confined in mesoporous channels and homogeneously dispersed in the bioactive glass substrate. Coalescence of the AgNPs occurred with higher Ag content. The in vitro antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was the same for MBG with Ag compositions in the range of 1–10 mole ratio in bioactive glass (MIC=10 mg/mL).
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