Abstract
BackgroundAging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. However, changes in lipid molecular species induced by aging are still unknown.We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis.MethodsSerum samples were collected from ten elderly men (71.7 ± 0.5 years old) and women (70.2 ± 1.0 years old), ten young men (23.9 ± 0.4 years old), and women (23.9 ± 0.7 years old). Serum levels of lipid molecular species were determined by liquid chromatography mass spectrometry-based lipidomics analysis.ResultsOur mass spectrometry analysis revealed increases in the levels of multiple triacylglycerol molecular species in the serum of elderly men and women. Moreover, serum levels of total ester-linked phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were increased by aging. In contrast, serum levels of specific ether-linked PC and PE molecular species were lower in elderly individuals than in young individuals.ConclusionsOur finding indicates that specific lipid molecular species, such as ether- and ester- linked phospholipids, may be selectively altered by aging.
Highlights
Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes
High plasma levels of specific TAG molecular species (e.g., TAG 50:0 and TAG 52:1) have been observed in patients with type 2 diabetes [6]. These findings suggest that the level of specific lipid molecular species may be beneficial as a biomarker for assessing the pathological status of metabolic syndrome
Serum levels of specific TAG molecular species were higher in elderly individuals than in young individuals
Summary
Aging is known to be associated with increased risk of lipid disorders related to the development of type 2 diabetes. Recent evidence revealed that change of lipid molecule species in blood is associated with the risk of type 2 diabetes. Changes in lipid molecular species induced by aging are still unknown. We assessed the effects of age on the serum levels of lipid molecular species as determined by lipidomics analysis. Aging is known to cause the development of metabolic syndrome, including type 2 diabetes and atherosclerosis [1]. Information regarding abnormal levels of triacylglycerol (TAG) and cholesterol in the blood is generally used to evaluate the risk for metabolic syndrome. Aging is known to be associated with increased risk of lipid disorders related to the development of metabolic syndrome [3]. On the basis of their structures and functions, lipids can be categorized into distinct classes, such as free fatty acids, glycerolipids, and glycerophospholipids
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