Effects of aging and hormonal status on bimanual motor coordination in the rhesus monkey

Abstract

Studies of age-related changes in motor function in nonhuman primates have been based exclusively on unimanual motor tasks. In this study, we examined whether aging affects bimanual motor coordination in the monkey model. In addition, we compared performance of ovariectomized and intact females on the task, to examine whether estrogen deficiency impairs motor function. The task required 29 rhesus monkeys (6–26 years old) to extract a maximum of 15 raisins from a testing hole-board. While the task could most efficiently be performed with two hands, other motor strategies were possible. The number of raisins extracted per minute was measured in each of eight sessions, the first and last of which were videotaped for analysis of motor patterns. The number of raisins retrieved per minute declined significantly with age. All monkeys improved with practice, but aged monkeys improved more slowly than young ones. The proportion of bimanual actions tended to increase between the first and the last sessions but was not significantly different between young and aged monkeys. Hormonal status did not affect performance. Finally, performance on the bimanual task was significantly correlated with performance on a previously administered unimanual motor test emphasizing speed, suggesting that age-related motor slowing may explain deficits in both tasks.