Abstract
Transgenic (TG) mice with cardiac-specific overexpression of nerve growth factor (NGF) have sympathetic hyperinnervation and elevated cardiac and plasma catecholamines. Nevertheless, left ventricular (LV) function was relatively unaffected in adult animals, attributed to NGF facilitating synaptic noradrenaline uptake. To examine whether ageing will uncover the expected adverse consequences following chronically enhanced cardiac sympathoadrenergic stimulation, we studied 15-month-old TG and wild-type (WT) mice.
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