Abstract
The testicular aromatase activity was significantly increased by administration of hCG to 18-day old rats, but not increased in 29-day old rats. 1,4,6-Androstatriene-3,17-dione did not inhibit the in vitro conversion of testosterone to 19-hydroxytestosterone by the testicular cell-free homogenates of the hCG-treated 18-day old rats, but strongly suppressed production of estrogen from 19-hydroxyandro-stenedione. On the other hand, the 19-hydroxylase activity of 18-day old rats stimulated by hCG was reduced to about 50% of the control value by SKF-525A, SU-4,885, SU-8,000 and SU-9,055 at their concentration of 10 −4M. From our results, it is postulated that there are two distinct steps in the process of aromatization of testosterone, the one, the primary 19-hydroxylation which is inhibited by SK.F-525A and SU-compounds, but not by 1,4,6-androstatriene-3,17-dione, and the other, aromatization of 19-hydroxylated androgen which is inhibited by both 1,4,6-androstatriene-3,17-dione and non-steroidal inhibitors.
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